List of STUDY Papers list on Celastrus paniculatus

1.The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenative Disorders II: Alzheimer's Disease.

Campos HC, da Rocha MD, Viegas FP, Nicastro PC, Fossaluzza PC, Fraga CA, Barreiro EJ, Viegas C Jr.

CNS Neurol Disord Drug Targets. 2010 Sep 29. [Epub ahead of print]PMID: 20874701 
2. Nootropic activity of Celastrus paniculatus seed.
Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G.

Pharm Biol. 2010 Mar;48(3):324-7.PMID: 20645820 
3.Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum.
Borrelli F, Borbone N, Capasso R, Montesano D, De Marino S, Aviello G, Aprea G, Masone S, Izzo AA.

J Ethnopharmacol. 2009 Apr 21;122(3):434-8. Epub 2009 Feb 11.PMID: 19429308 
4.Wound healing activity and docking of glycogen-synthase-kinase-3-beta-protein with isolated triterpenoid lupeol in rats.
Harish BG, Krishna V, Santosh Kumar HS, Khadeer Ahamed BM, Sharath R, Kumara Swamy HM.

Phytomedicine. 2008 Sep;15(9):763-7. Epub 2008 Jan 28.PMID: 18222664 
5. Identification of a new sesquiterpene polyol ester from Celastrus paniculatus.
Borbone N, Borrelli F, Montesano D, Izzo AA, Marino SD, Capasso R, Zollo F.

Planta Med. 2007 Jul;73(8):792-4. Epub 2007 Jun 28.PMID: 17599283 
6. Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour.
Rajkumar R, Kumar EP, Sudha S, Suresh B.

Fitoterapia. 2007 Feb;78(2):120-4. Epub 2006 Nov 14.PMID: 17169502 
7. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells.
Godkar PB, Gordon RK, Ravindran A, Doctor BP.

Phytomedicine. 2006 Jan;13(1-2):29-36. Epub 2005 Jun 28.PMID: 16360930 
8. New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus.
Borrelli F, Borbone N, Capasso R, Montesano D, Izzo AA, De Marino S, Capasso F, Ferrara L, Longo R, Zollo F.
Planta Med. 2004 Jul;70(7):652-6.PMID: 15254858 
9.Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain.
Godkar PB, Gordon RK, Ravindran A, Doctor BP.

J Ethnopharmacol. 2004 Aug;93(2-3):213-9.PMID: 15234755 
10.Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury.
Godkar P, Gordon RK, Ravindran A, Doctor BP.

Fitoterapia. 2003 Dec;74(7-8):658-69.PMID: 14630170 
11.Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens.
Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy D, Golan-Goldhirsh A.

Phytother Res. 2003 Nov;17(9):1123-5.PMID: 14595602 
12.Antioxidant property of Celastrus paniculatus willd.: a possible mechanism in enhancing cognition.
Kumar MH, Gupta YK.

Phytomedicine. 2002 May;9(4):302-11.PMID: 12120811 
13.Rapid in vitro multiplication and restoration of Celastrus paniculatus Willd. sub sp. paniculatus (Celastraceae), a medicinal woody climber.
Nair LG, Seeni S.

Indian J Exp Biol. 2001 Jul;39(7):697-704.PMID: 12019765 
14.Improved polygalacturonase production from Bacillus sp. MG-cp-2 under submerged (SmF) and solid state (SSF) fermentation.
Kapoor M, Kuhad RC.

Lett Appl Microbiol. 2002;34(5):317-22.PMID: 11967052 
15.Indian medicinal plants as antiradicals and DNA cleavage protectors.
Russo A, Izzo AA, Cardile V, Borrelli F, Vanella A.

Phytomedicine. 2001 Mar;8(2):125-32.PMID: 11315755 
16.Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus.
Gattu M, Boss KL, Terry AV Jr, Buccafusco JJ.

Pharmacol Biochem Behav. 1997 Aug;57(4):793-9.PMID: 9259008 
17.Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats.
Nalini K, Karanth KS, Rao A, Aroor AR.

J Ethnopharmacol. 1995 Jul 7;47(2):101-8.PMID: 7500635 
18.Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities.
Ahmad F, Khan RA, Rasheed S.

J Ethnopharmacol. 1994 May;42(3):193-8.PMID: 7934089 
19.Antispermatogenic action of Celastrus paniculatus seed extract in the rat with reversible changes in the liver.
Bidwai PP, Wangoo D, Bhullar N.

J Ethnopharmacol. 1990 Mar;28(3):293-303.PMID: 2335957 
20.Effect of Celastrus paniculatus seed extract on the brain of albino rats.
Bidwai PP, Wangoo D, Bhullar NK.

J Ethnopharmacol. 1987 Dec;21(3):307-14. No abstract available. PMID: 3441139 



Arch Int Pharmacodyn Ther. 1963 Jul 1;144:34-50. No abstract available. PMID: 14043652

22 . Central Nervous System Agents Med Chem. 2010 Sep 1;10(3):238-46.
Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha.
Ven Murthy MR, Ranjekar PK, Ramassamy C, Deshpande M.
Department of Medical Biology, Faculty of Medicine,
Laval University, Laval,Québec, Canada G1K 7P4, Canada.
Ayurveda is a Sanskrit word, which means "the scripture for longevity". It represents an ancient system of traditional medicine prevalent in
India and in several other south Asian countries. It is based on a holistic view of treatment which is believed to cure human diseases through establishment of equilibrium in the different elements of human life, the body, the mind, the intellect and the soul. Ayurveda dates back to the period of the Indus Valley civilization (about 3000 B.C) and has been passed on through generations of oral tradition, like the other four sacred texts (Rigveda, Yajurveda, Samaveda and Atharvanaveda) which were composed between 12(th) and 7(th) century B.C. References to the herbal medicines of Ayurveda are found in all of the other four Vedas, suggesting that Ayurveda predates the other Vedas by at least several centuries. It was already in full practice at the time of Buddha (6(th) century B.C) and had produced two of the greatest physicians of ancient India, Charaka and Shushrutha  who composed the basic texts of their trade, the Samhitas. By this time, ayurveda had already developed eight different subspecialties of medical treatment, named Ashtanga, which included surgery, internal medicine, ENT, pediatrics, toxicology,  health and longevity, and spiritual healing . Ayurvedic medicine was mainly  composed of herbal preparations which were occasionally combined with different levels of other compounds, as supplements. In the Ayurvedic system, the herbs used for medicinal purposes are classed as brain tonics or rejuvenators. Among the plants most often used in Ayurveda are, in the descending order of importance: (a) Ashwagandha, (b) Brahmi, (c) Jatamansi, (d) Jyotishmati, (e) Mandukparni, (f) Shankhapushpi, and (g) Vacha.

23. Brahmi rasayana Improves Learning and Memory in Mice
Hanumanthachar Joshi and Milind Parle
Evid Based Complement Alternat Med. 2006 March; 3(1): 79–85. Published online 2006 January 16. doi: 10.1093/ecam/nek014.
PMCID: PMC1375237
24. Ancient-modern concordance in Ayurvedic plants: some examples. S Dev
Environ Health Perspect. 1999 October; 107(10): 783–789. PMCID: PMC1566595